It has been reported that treatment with acetonic extract. Activity of single components of ferula hermonis on male. The present invention is directed toward a pharmaceutically active composition extracted from ferula hermonis by a process comprising contacting ferula hermonis with a supercritical carbon dioxide fluid at conventional supercritical fluid extraction temperatures and pressures, and for a time sufficient to remove the active composition from ferula hermonis, and recovering the pharmaceutical. Daucane sesquiterpenes from ferula hermonis request pdf. This page was last edited on 15 december 2019, at 09. All structured data from the file and property namespaces is available under the creative commons cc0 license. Antiausterity activity of secondary metabolites from the.
Acute and subchronic invivo effects of ferula hermonis l. Medicinal plants as alternative treatments for female. The outstanding species ferula hermonis zallouh, lebanese viagra recording the highest usereports for its aphrodisiac activity was believed by all informants to be critically under major non sustainable harvesting threat due its extensive use and a. Ferula communis seeds giant fennel, meeting seed plant world seeds. The invention relates to a process for the preparation of ferutinine ia from ferula spp extracts comprising basic hydrolysis of the extracts and treatment with ppivaloyloxybenzoic acid.
Ferula hermonis is a middle eastern species of plant in the family apiaceae native to syria, israel and lebanon. Ferula hermonis apiaceae is a well known middleeastern medicinal plant. The acute administration stimulated sexual motivation in. Zallouh ferula hermonis is a plant that grows at a height of approximately 2,000 meters above sea level on the side of mount hermoun between lebanon and syria. This article is within the scope of wikiproject plants, a collaborative effort to improve the coverage of plants and botany on wikipedia.
However, there are few reports on the in vitro anticancer potential of fh extract. The influence of the single components of ferula hermonis extract on sexual behavior was studied in male rats. Breast and colon cancers are leading causes of cancerrelated deaths globally. Sexually potent and sluggishimpotent male rats were orally treated with an extract of ferula hermonis 30 and 60 mgkg. In vitro screening for antiacetylcholiesterase, anti. Files are available under licenses specified on their description page. Herbal remedies used for the treatment of infertility in.
Phytochemistry and pharmacology of ferula hermonis boiss. The leaves are tripinnate or even more finely divided, with a stout basal sheath clasping. Over 100 species of ferula are widely distributed throughout the middle east. Ferula hermonis, a wellknown species of the genus ferula found in lebanon and syria, has a brilliant history in traditional medicine as it has been used for the treatment of erectile dysfunction. It makes an enormous hardy tuber in time, and can make a spectacular addition to a wild. Its dried roots have been traditionally used aphrodisiac agents. The present study aims to investigate the activities of ferula hermonis boiss. Ferula hermonis, a native plant of syria and lebanon locally known as zalloh, grows on mount hermon at more than 2500 m. Pdf effects of hexane root extract of ferula hermonis. This superb and spectacular giant from the mediterranean has dark green leaves, divided many times into delicate, feathery segments. Ferula hermonis impairs sexual behavior in hormoneprimed.
Nmr signals were completely assigned by the application of the modern nmr techniques. Inhibition of the growth and development of mosquito. Estrogenic activities of ten medicinal herbs from the. Ferula hermonis boiss apiaceae is known in the midleast as zallouh. Some other aryl esters of jaeschkeanadiol and 2,3epoxide jaeschkeanadiol, as well as. Ovariectomized rats hormonally primed with estradiol benzoate 1. The antiinflammatory properties of three major daucane esters, ferutinin 1 teferin 2 and teferidin 3, isolated from the root oil of ferula hermonis, were assessed by the carrageenan. A preliminary phytochemical investigation of the three extracts revealed the presence of alkaloids, flavonoids, proteins, lipids, phenolic compounds, saponins, sterols and amino acids.
A comparative study of ferula hermonis root extracts and. This study was conducted to assess the larvicidal activity of ferula hermonis boiss,achillea millefolium, salvia officnalis, psidium guaja and matricaria chamomilla extract against culex pipiens. The roots of ferula hermonis boiss yielded two new daucane esters, 144hydroxybenzoyloxydauc4,8diene 1 and 144hydroxy3methoxybenzoyloxydauc4,8diene 2, together with the four known sesquiterpenes jaeschkeanadiol phydroxybenzoate 3, jaeschkeanadiol benzoate 4, jaeschkeanadiol 5, and epoxyjaeschkeanadiol 6. A highperformance liquid chromatographic hplc method for the determination of. It is a small shrub with thin leaves, little white or yellow flowers and hairy roots. Among promising larvicidal sources is the use of plant extracts, which will play an important role in the future. In the present study, we evaluated the effects of single components of ferula hermonis extract on female rat sexual behaviour.
Antiinflammatory sesquiterpenes from the root oil of. Daucane sesquiterpenes from ferula hermonis journal of. Our results showed that the ferula hermonis root hexane extract fhrh can induce dosedependent cytotoxic effects in breast and colon cancer cells with mtt ic 50 values of 18. Antimicrobial antioxidant daucane sesquiterpenes from.
They are herbaceous perennial plants growing to 14 m tall, with stout, hollow, somewhat succulent stems. Estrogenic activities of ten medicinal herbs from the middle east ibtesam a. Ferula hermonis fh is reported to have diverse therapeutic effects. In this study ferula hermonis were collected and evaluated for cytotoxic activity. It has long been used traditionally as an aphrodisiac agent. Ethnopharmacological survey of medicinal plants used in. Ferula from latin ferula, rod is a genus of about 170 species of flowering plants in the family apiaceae, native to the mediterranean region east to central asia, mostly growing in arid climates. The method includes saponification of samples and extraction of. Sexual receptivity, proceptivity and paced mating behavior were evaluated in ovariectomized females primed with estradiol benzoate eb and progesterone p and then treated with f hermonis extract acutely 30 and 60 mgkg or subehronically 1 and 10 mgkg daily for 10 consecutive days. Pdf influence of ferula hermonis acetonic extract on. Role of ferutinin in the impairment of female sexual. The enormous flowerheads contain countless tiny, bright yellow flowers in early summer. Ferula communis seeds giant fennel, meeting seed plant. In the last decade, scientists paid attention to study chemistry and biological activity of the plant.
Download fulltext pdf download fulltext pdf antiinflammatory sesquiterpenes from the root oil of ferula hermonis article pdf available in phytotherapy research 255. Ferutinin 1, the major constituent of ferula hermonis and other ferula species, is a sesquiterpene ester with remarkable estrogenic activity, beside other valuable medicinal properties. Apiaceae, commonly known as shilshelzallouh, hashishatalkattira or the lebanese viagra, is a small shrub that grows abundantly on the hermon mountain between syria and lebanon. The invention relates also to the use of the extracts and ferutinine in the cosmetic and dermatological field. Female sexual dysfunction fsd is a complex and multifactorial condition. Pdf antiinflammatory sesquiterpenes from the root oil of.
Our results showed that the ferula hermonis root hexane. Text is available under the creative commons attributionsharealike license. Sexually potent and sluggishimpotent animals were orally treated acutely 2. Opposite effect of acute and subchronic treatments with. Plants are a potential source of natural products that may be used for the treatment of cancer. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks. Read antimicrobial antioxidant daucane sesquiterpenes from ferula hermonis boiss, phytotherapy research on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. This page was last edited on 21 december 2019, at 20. The antiinflammatory effect of both 1 and 2 was observed with a dose of 100 mgkg, while compound 3 did not show any. Pharmaceutically active composition extracted from ferula. Effects of hexane root extract of ferula hermonis boiss. In this study we investigated the phytoconstituents calluna vulgaris, ferula hermonis and tribulus terrestris, and then assessed their possible biological activities by using standard methods. Samsung hm160hi ata device driver download updating your drivers with driver a usb device driver free download unable to boot from usb or cd device data download game moto gp terbaru jar ferula hermonis pdf download.
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